by DC680
It doesn't matter how many people are playing the game the rules are the same. So if you play with 4 roles you can each control 2 but the initial turn order must remain constant, just like if four actual people were playing. Also, you cannot mingle cards between players unless taking the share knowledge action or using an ability that allows it.The only rule change when increasing the number of roles is decreasing your starting hand size. I've found that increasing the role count actually increases the difficulty of any pandemic game.