The best and worst roles depend on the number of players. In particular, the Nurse is stronger with more players, because her special ability lasts for every turn until her next turn (and the Railwayman or Sailor enhance the ability further because they can take the Nurse as a passenger if she is needed somewhere else). The Royal Academy Scientist's ability to use any card to purify water is stronger with fewer players, as hand limits become more important when there are not enough players to collect all four colors.
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